FRAYannis

Scourge

Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with developmental delays, mild to moderate intellectual disability, and characteristic physical features. The parents of the affected individual are usually genetically normal. The incidence of the syndrome increases with the age of the mother, from less than 0.1% for 20-year-old mothers to 3% for those of age 45. It is believed to occur by chance, with no known behavioral activity or environmental factor that changes the probability. Three different genetic forms have been identified. The most common, trisomy 21, involves an extra copy of chromosome 21 in all cells. The extra chromosome is provided at conception as the egg and sperm combine. Translocation Down syndrome involves attachment of extra chromosome 21 material. In 1–2% of cases, the additional chromosome is added in the embryo stage and only affects some of the cells in the body; this is known as mosaic Down syndrome. Down syndrome can be identified during pregnancy by prenatal screening, followed by diagnostic testing, or after birth by direct observation and genetic testing. Since the introduction of screening, Down syndrome pregnancies are often aborted (rates varying from 50 to 85% depending on maternal age, gestational age, and maternal race/ethnicity). There is no cure for Down syndrome. Education and proper care have been shown to provide better quality of life. Some children with Down syndrome are educated in typical school classes, while others require more specialized education. Some individuals with Down syndrome graduate from high school, and a few attend post-secondary education. In adulthood, about 20% in the United States do some paid work, with many requiring a sheltered work environment. Caregiver support in financial and legal matters is often needed. Life expectancy is around 50 to 60 years in the developed world, with proper health care. Regular screening for health issues common in Down syndrome is recommended throughout the person's life. Down syndrome is the most common chromosomal abnormality, occurring in about 1 in 1,000 babies born worldwide, and one in 700 in the US. In 2015, there were 5.4 million people with Down syndrome globally, of whom 27,000 died, down from 43,000 deaths in 1990. The syndrome is named after British physician John Langdon Down, who dedicated his medical practice to the cause. Some aspects were described earlier by French psychiatrist Jean-Étienne Dominique Esquirol in 1838 and French physician Édouard Séguin in 1844. The genetic cause was discovered in 1959.

Being

Michael Akpovie Olise (; o-LEE-say; Urhobo: [à.k͡pɔ̀.vjɛ̀ ɔ̀.lí.sɛ̀]; French: [maikəl olisɛ]; born 12 December 2001) is a professional footballer who plays as a winger or attacking midfielder for Bundesliga club Bayern Munich and the France national team. Widely regarded as one of the best players in the world, he is known for his creative playmaking, tactical intelligence, dribbling, and flair. Born in London, Olise is a product of various English academies. He made his professional debut for Championship club Reading in 2019 and won EFL Young Player of the Season in 2021. He was then signed by Premier League club Crystal Palace, where he spent three seasons and set various club and league records. He was nominated for PFA Young Player of the Year in 2024, before moving to Bayern Munich. At Bayern, Olise emerged as one of the most dominant wingers in the world. In his debut campaign, he was named Bundesliga Rookie of the Season and was nominated for the Ballon d'Or. The following year, he was named VDV Bundesliga Player of the Season and became the league's back-to-back assist leader. He has helped the club win two league titles and a DFB-Pokal. Olise represented France at youth level and was included in their squad for the 2024 Summer Olympics, where he was top assister and received a silver medal. He made his debut for the senior French team in September 2024 and played at the 2026 FIFA World Cup where he registered a tournament-high seven assists — the most for any player in a single World Cup edition.

Being

Jean Louis Marie "Jean-Marie" Le Pen (French: [ʒɑ̃maʁi lə pɛn]; 20 June 1928 – 7 January 2025) was a French politician who founded the far-right National Front (now National Rally) party. He served as the party's president from 1972 to 2011 and as its honorary president from 2011 to 2015. Born in Brittany, Le Pen focused on issues related to immigration to France, the European Union, traditional culture and values, law and order, and France's high rate of unemployment. His progression in the 1980s is known as the "lepénisation of minds" due to its noticeable effect on mainstream political opinion. His controversial speeches and his integration into public life made him a figure who polarized opinion. He was convicted of statements downplaying the Holocaust, and fined for incitement to discrimination regarding remarks made about Muslims in France. He was expelled from the party by his daughter Marine in 2015 after making controversial statements. Le Pen's longevity in politics and his five attempts to become president of France made him a major figure in French political life. His unexpected progress to the second round in the 2002 presidential election—when he was beaten in a landslide by incumbent Jacques Chirac—left its mark on French public life, and the "21st of April" is now a frequently used expression in France. He served three terms in the National Assembly and was a member of the European Parliament (MEP) from 1984 to 2019.

Being

Christopher Columbus (; between 25 August and 31 October 1451 – 20 May 1506) was an Italian explorer and navigator from the Republic of Genoa who completed four Spanish transatlantic voyages in the name of the Catholic Monarchs, opening the way for the widespread European exploration and colonization of the Americas. His expeditions were the first known European contact with the Caribbean and Central and South America. The name Christopher Columbus is the anglicization of the Latin Christophorus Columbus. Growing up on the coast of Liguria, he went to sea at a young age and traveled widely, as far north as the British and Irish Isles and as far south as what is now Ghana. He married Portuguese noblewoman Filipa Moniz Perestrelo, who bore a son, Diego, and was based in Lisbon for several years. He later took a Castilian mistress, Beatriz Enríquez de Arana, who bore a son, Ferdinand. Largely self-educated, Columbus was knowledgeable in geography, astronomy, and history. He developed a plan to seek a western sea passage to the East Indies, hoping to profit from the lucrative spice trade. After the Granada War, and Columbus's persistent lobbying in multiple kingdoms, the Catholic Monarchs, Queen Isabella I and King Ferdinand II, agreed to sponsor a journey west. Columbus left the Port of Palos in August 1492 with three ships and made landfall in the Americas on 12 October, ending the period of human habitation in the Americas now referred to as the pre-Columbian era. His landing place was an island in the Bahamas, known by its native inhabitants as Guanahani. He then visited the islands now known as Cuba and Hispaniola, establishing a colony in what is now Haiti. Columbus returned to Castile in early 1493, with captured natives. Word of his voyage soon spread throughout Europe. Columbus made three further voyages to the Americas, exploring the Lesser Antilles in 1493, Trinidad and the northern coast of South America in 1498, and the east coast of Central America in 1502. Many of the names given to geographical features by Columbus, particularly the names of islands, are still in use. He gave the name indios ('Indians') to the Indigenous peoples he encountered. The extent to which he was aware that the Americas were a wholly separate landmass is uncertain; he never clearly renounced his belief he had reached the Far East. As a colonial governor, Columbus was accused by some of his contemporaries of significant brutality and removed from the post. Columbus's strained relationship with the Crown of Castile and its colonial administrators in America led to his arrest and removal from Hispaniola in 1500, and later to protracted litigation over the privileges he and his heirs claimed were owed to them by the Crown. Columbus's expeditions inaugurated a period of exploration, conquest, and colonization that lasted for centuries, thus bringing the Americas into the European sphere of influence. The transfer of plants, animals, precious metals, culture, human populations, technology, diseases, and ideas between the Old World and New World that followed his first voyage are known as the Columbian exchange, named after him. These events and the effects which persist to the present are often cited as the beginning of the modern era. Diseases introduced from the Old World contributed to the genocide of Hispaniola's Indigenous peoples, who were also subject to enslavement and other mistreatments by Columbus's government. Increased public awareness of these interactions has led to Columbus being less celebrated in Western culture, which has historically idealized him as a heroic discoverer. Numerous places have been named for him.

Concept

Anilingus (also spelled analingus) is an oral and anal sex act (anal–oral contact or anal–oral sex) in which one person stimulates the anus of another by using their tongue or lips. The anus has a relatively high concentration of nerve endings and can be an erogenous zone, so the recipient may receive pleasure from external anal stimulation, whereas pleasure for the giver is usually based more on the principle of the act. People may engage in anilingus for its own sake, before anal penetration, or as part of foreplay. All sexual orientations may participate in the act. Studies confirm anilingus to be one of the sexual practices between women, though only practiced by a minority. Safer sex practices generally revolve around hygiene so as to prevent fecal–oral route transmission of diseases. Extra precautions include STI testing, dental dams, or enemas.